A hydroxyl linker based on the tetrahydropyranyl (THP) protecting group has been developed by Thompson
and Ellmann. All type of alcohols readily add to dihydropyran and the resulting THP
protecting group is stable to strong base, but easily cleaved with acid. This linker
is attached to a Merrifield resin.
The trityl group is a good acid-labile protecting group for a lot of heteroatoms.
The trityl group has been used to anchor alcohols in the synthesis of a library of β-mercaptoketones.
