New Synthesis of Substituted Quinoline N-Oxides via Cyclization of Alkylidene O-Nitroarylacetonitriles
Zbigniew Wrobel, Andrej Kwast, Mieczyslaw Makosza, Synthesis 1993, p. 31-32
Substituted quinoline N-oxides are prepared via base induced cyclization of alkylidene derivates of o-nitroarylacetonitriles which are readily available via the vicarious nucleophilic substitution cyanomethylation of nitroarenes followed by Knoevenagel condensation.
