Combinatorial Chemistry Review

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Numerical representation of a compound or library which describes in a computationally simple fashion a set of attributes (descriptors), such as atom connectives, 3-D structure or physical properties.

Flow Cytometry
Technique for characterizing or separating particles such as beads or cells, usually on the basis of their relative fluorescence.

Fluidic System
Device for synthesis or screening in which fluids such as reagents or assay buffers maybe directed to specified locations by the opening and closing of valves in a stationary network of tubes and wells.

Fluorous Synthesis
Approach for solution phase synthesis which takes advantage of the ability of highly fluorinated groups to partition out of aqueous and most organic solutions into a third phase consisting of a fluorinated solvent.

Frontal Affinity Chromatography (FAC)
FAC is a quantitative method that enables sensitive and reproducible measurements of interactions between lectins and oligosaccharides. The method is suitable even for the measurement of low-affinity interactions and is based on a simple procedure and a clear principle.

Fully Combinatorial
Containing, or designed to contain, all possible combinations of building blocks. Pool/split libraries are generally fully combinatorial while parallel synthesis libraries may not be.