Combinatorial Chemistry Review

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a) One of a set of surrogate analytes which are used in a decoding process;
b) pendant function which allows a molecule to be selected from a mixture.

A type of reaction vessel consisting of a porous mesh which encloses the resin but allows passage of reagents and solvents when immersed in an appropriate secondary container. Several tea-bags may be treated in a single vessel without mixing of the enclosed resins; manipulation of multiple tea-bags allows preparation of libraries by pool/split or directed sorting techniques.

Trademark of Rapp Polymere GmbH, Tubingen, Germany. Beaded solid support with a crosslinked polystyrene core and grafted linear poly(ethylene glycol) (PEG) chains with terminal functional groups.

Thematic libraries synthesis
Over the past several years, combinatorial chemistry has gradually realigned itself with changing business needs. In many organizations diversity-driven library production intended to broadly cover druglike chemical space has to a large extent been replaced by thematic as well as project-directed libraries. Thematic libraries are particularly useful for a platform target-based approach to drug discovery because the control of a common biochemical theme (e.g., the use of enzyme inhibitors, peptidomimetics of receptor ligands, etc.) can often cross over providing leads in several therapeutic areas.

Three - dimensional Quantitative Structure - Activity Relationship (3D-QSAR)
The analysis of the quantitative relationship between the biological activity of a set of compounds and their spatial properties using statistical methods.

Traceless Linker
Type of linker which leaves no residue on the compound after cleavage.

Unbiased Library
Library prepared from building blocks and scaffold chosen without bias towards a particular target.

Universal Library
A hypothetical compound collection which will show activity in all assays; a library with useful activity in many assays.

Virtual Library
A library which has no physical existence, being constructed solely in electronic form or on paper. The building blocks required for such a library may not exist, and the chemical steps for such a library may not have been tested. These libraries are used in the design and evaluation of possible libraries.

Virtual Screening
Selection of compounds by evaluating their desirability in a computational model. Also termed in silico screening.

X-Ray Photoelectron Spectroscopy
Technique for determining the elemental composition at a solid surface by measuring the energy of elctrons emitted in response to X-rays of different frequency. Has been applied to solid-phase combinatorial chemistry by incorporating a tracer atom in the linker.